Beyond Nutrition: Exploring the Neuroprotective Properties of Moringa oleifera Oil through Cellular Signaling
UDI, Onoriode Andrew *
Department of Human Anatomy, Faculty of Basic Medical Science, Federal University Otuoke, Bayelsa State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Moringa oleifera oil, traditionally valued for its nutritional composition, is garnering increasing attention for its potential therapeutic applications. This review delves beyond the established nutritional benefits of Moringa oleifera oil to explore its neuroprotective properties, specifically focusing on the underlying mechanisms involving cellular signaling pathways. The review examine existing in vitro and in vivo studies investigating the impact of Moringa oleifera oil and its bioactive compounds on neuronal survival, inflammation, oxidative stress, and synaptic plasticity in the context of neurodegenerative diseases and neurological disorders. The study aims to elucidate the role of specific signaling cascades, such as the Nrf2/ARE pathway, PI3K/Akt pathway, and MAPK pathways, in mediating the observed neuroprotective effects. By synthesizing current research, this review provides a comprehensive understanding of the potential of Moringa oleifera oil as a neuroprotective agent and highlights key areas for future investigation in preclinical and clinical settings to validate its efficacy and safety in preventing or mitigating neurological damage. Ultimately, this exploration seeks to establish a scientific rationale for the therapeutic use of Moringa oleifera oil in promoting brain health and combating neurodegenerative conditions.
Keywords: Moringa oleifera oil, neuroprotection, cellular signaling, oxidative stress, inflammation